Based on the migration of Ag-transporting cells (ATC) into lymphoid follicles and the phenotypic similarity between FDC and ATC, one hypothesis is that ATC may represent emigrating FDC precursors. Furthermore, additional review of associations between possible prognostic factors and recurrence-free survival showed no statistical significance for age, sex, intra-abdominal involvement, size, lymph node involvement or distant metastasis at time of presentation, mitotic rate, necrosis, or the use of neoadjuvant or adjuvant therapy.4 Again, this may be due to the small number of cases available for study and the retrospective nature of the investigations. Imai Y, Maeda K, Yamakawa M, Karube Y, Matsuda M, Dobashi M, Sato H, Terashima K. Adv Exp Med Biol.  |  The origin of follicular dendritic cells (FDC) is unresolved, and as such, remains controversial. The absence of cytokeratin staining rules out the diagnostic possibility of carcinoma with a spindled or sarcomatoid morphology. 0000032127 00000 n

Pierre Sohier, MD, PhD, Stéphanie Matar, MD, Jean-François Meritet, PharmD, Sara Laurent-Roussel, MD, Nicolas Dupin, MD, PhD, Selim Aractingi, MD, PhD, Samarina M. A. Musaad, MB BS, MAACB, FAACB, MPH, FRCPA, Tamika Regnier, BMedSc, Mark Shephard, OAM, BSc(Hons), MSc, MAIMS, MAACB, FFSc(RCPA), PhD, Anne Shephard, BSc(Hons), Peter Graham, MAppSci, Rizzi DeLeon, BMedSc, Samantha Shepherd, BForSc, Mark Inman, MD, Andrew W. Lyon, BSc(Hons), PhD, Oliver A. S. Lyon, BSc(Hons), Martha E. Lyon, BSc(Hons), BEd, MSc, PhD, Nadia Ayala-Lopez, MLS(ASCP), PhD, James H. Nichols, PhD, Joshua R. Menke, MD, Michael A. Spinner, MD, Yasodha Natkunam, MD, PhD, Roger A. Warnke, MD, Ranjana H. Advani, MD, Dita A. Gratzinger, MD, PhD, Richard Torres, MD, MS, Eben Olson, PhD, Robert Homer, MD, PhD, Darryl T. Martin, PhD, Michael J. Levene, PhD, Sudhir Perincheri, MBBS, PhD, Preston C. Sprenkle, MD, Peter A. Humphrey, MD, PhD, William C. McDonald, MD, Kelsey N. McDonald, PhD, Jordan A. Helmer, BS, Bridget Ho, CCRC, Amber Wang, MD, Nilanjana Banerji, PhD, This site uses cookies. Unlike other DCs and macrophages, FDCs lack MHC class II antigen molecules and express few pattern-recognition receptors, so they have little ability to capture non-opsonized antigens. Follicular dendritic cells in health and disease. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Overall, extranodal FDC sarcomas are most often described as highly cellular, although most reports suggest that the histology is low grade with only mild to moderate atypia. Immunology. Interaction between FDCs precursors and lymphoid cells mediated by TNF-a and lymphotoxin (LT) is crucial for normal FDC development and maintenance. [5], Follicular DCs develop from putative mesenchymal precursors. By continuing to browse this site, you agree to its use of cookies as described in our, I have read and accept the Wiley Online Library Terms and Conditions of Use.


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