(2018). In most articles, tissue engineering of the outermost layer of the eye is known as ocular surface regeneration. Acta XXV Concilium Ophthalmol. Sequentially-crosslinked bioactive hydrogels as nano-patterned substrates with customizable stiffness and degradation for corneal tissue engineering applications. doi: 10.1016/j.matpr.2018.04.155, Karimi, M., Bahrami, S., Ravari, S. B., Zangabad, P. S., Mirshekari, H., Bozorgomid, M., et al. J. Ophthalmol. (2018).


(2018). Zhong et al. Veter.
They designed a highly organized structure with aligned microgrooves which directed parallel cell alignment, and allowed matrix organization, similar to that of native corneal stromal lamella (Buznyk et al., 2015).

Acs Nano 4, 6760–6766.

Inasmuch as biopolymers have shown promising results in tissue engineering and wound healing, their deployment in corneal wound healing has attracted lots of attention (Gholipourmalekabadi et al., 2018; Zarrintaj et al., 2018c).

doi: 10.1007/s12015-017-9740-6, Quantock, A. J., Winkler, M., Parfitt, G. J., Young, R. D., Brown, D. J., Boote, C., et al. 12, 59–69. (2017). identified an active matrix component [Heavy chain-hyaluronan/pentraxin3 (HC-HA/PTX3)] that was shown to exert the anti-inflammatory and anti-scarring effects of AM. After a 9-months follow-up, SLATE was well integrated with surrounding hot tissue without a sign of rejection and provoking inflammation (Gouveia et al., 2017). However, despite the advancement of surgical techniques for corneal transplantation, demand for the surgery can never be met due to a global shortage of donor cornea. Synthetic skirts have shown better mechanical biocompatibility with the sclera, in addition to more comfortable fabrication and better handling during the surgery. Bioengineered scaffolds for stem cell applications in tissue engineering and regenerative medicine. (2016). Solar Cells 125, 102–112. Remarkable developments of novel biomaterials and stem cell-based tissue cultivation and expansion techniques during the past few decades might enable the mass production of synthetic corneal tissue and are expected to provide innovative treatment methods for corneal disease. doi: 10.1167/iovs.16-20834, Tóth, E., Beyer, D., Zsebik, B., Vereb, G., and Takács, L. (2017). A biosynthetic alternative to human donor tissue for inducing corneal regeneration: 24-month follow-up of a phase 1 clinical study.

Exp. 65, 123–136. Ther.

In fact, RGTAs were engineered to bind to heparan sulfate binding sites on proteins of the ECM. doi: 10.1136/bjophthalmol-2013-303141, Weng, Y., Liu, J., Jin, S., Guo, W., Liang, X., and Hu, Z. J. Biomater. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice.

Corneas were harvested at day 3 after injury.


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